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Barrett's esophagus: cancer and molecular biology

Identifieur interne : 006196 ( Main/Exploration ); précédent : 006195; suivant : 006197

Barrett's esophagus: cancer and molecular biology

Auteurs : Michael K. Gibson [États-Unis] ; Arashinder S. Dhaliwal [États-Unis] ; Nicholas J. Clemons [Australie] ; Wayne A. Phillips [Australie] ; Katerina Dvorak ; Daniel Tong [Hong Kong] ; Simon Law [Hong Kong] ; E. Daniel Pirchi [Argentine] ; Jari R S Nen [Finlande] ; Mark J. Krasna ; Kaushal Parikh [Pays-Bas] ; Kausilia K. Krishnadath [Pays-Bas] ; Yu Chen [Royaume-Uni] ; Leonard Griffiths [Royaume-Uni] ; Benjamin J. Colleypriest [Royaume-Uni] ; J. Mark Farrant [Royaume-Uni] ; David Tosh [Royaume-Uni] ; Kiron M. Das ; Manisha Bajpai

Source :

RBID : ISTEX:8006CBE7B620E930DBBFBF17425622A68D2F8993

Descripteurs français

English descriptors

Abstract

The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF‐κB, and IL‐6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally invasive esophagectomy versus open surgery; outcomes for patients with pharyngolaryngoesophagectomy; the applications of neoadjuvant chemotherapy and chemoradiotherapy; animal models examining the surgical models of BE and esophageal adenocarcinoma; the roles of various morphogens and Cdx2 in BE; and the use of in vitro BE models for chemoprevention studies.

Url:
DOI: 10.1111/nyas.12252


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<term>Gene expression</term>
<term>Hedgehog</term>
<term>Homeobox genes</term>
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<term>Mediastinal lymphadenectomy</term>
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<term>Morphogens</term>
<term>Morphological changes</term>
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<term>Nodal involvement</term>
<term>Nodal metastases</term>
<term>Node</term>
<term>Normal esophagus</term>
<term>Open surgery</term>
<term>Oxidative stress</term>
<term>Palliative roles</term>
<term>Paracrine fashion</term>
<term>Parahox cluster</term>
<term>Pathogenesis</term>
<term>Pathway</term>
<term>Pharyngogastric anastomosis</term>
<term>Phenotype</term>
<term>Primary tumor</term>
<term>Progression</term>
<term>Radical esophagectomy</term>
<term>Randomized</term>
<term>Recurrence</term>
<term>Resection</term>
<term>Risk reduction</term>
<term>Similar results</term>
<term>Smoothened inhibitor</term>
<term>Sonic hedgehog</term>
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<term>Surgery</term>
<term>Surgical</term>
<term>Surgical resection</term>
<term>Systematic review</term>
<term>Therapeutic options</term>
<term>Transcription</term>
<term>Transcription factor</term>
<term>Transhiatal</term>
<term>Transhiatal esophagectomy</term>
<term>Transthoracic</term>
<term>Transthoracic esophagectomy</term>
<term>Transthoracic resection</term>
<term>Upfront chemoradiation</term>
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</keywords>
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<term>Intestinal differentiation</term>
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<term>Surgical</term>
<term>Surgical resection</term>
<term>Systematic review</term>
<term>Therapeutic options</term>
<term>Transcription</term>
<term>Transcription factor</term>
<term>Transhiatal</term>
<term>Transhiatal esophagectomy</term>
<term>Transthoracic</term>
<term>Transthoracic esophagectomy</term>
<term>Transthoracic resection</term>
<term>Upfront chemoradiation</term>
<term>Various morphogens</term>
<term>York academy</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Chirurgie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract">The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF‐κB, and IL‐6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally invasive esophagectomy versus open surgery; outcomes for patients with pharyngolaryngoesophagectomy; the applications of neoadjuvant chemotherapy and chemoradiotherapy; animal models examining the surgical models of BE and esophageal adenocarcinoma; the roles of various morphogens and Cdx2 in BE; and the use of in vitro BE models for chemoprevention studies.</div>
</front>
</TEI>
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<country>
<li>Argentine</li>
<li>Australie</li>
<li>Finlande</li>
<li>Hong Kong</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region>
<li>Hollande-Septentrionale</li>
<li>Pennsylvanie</li>
<li>Victoria (État)</li>
</region>
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<li>Amsterdam</li>
<li>Melbourne</li>
<li>Pittsburgh</li>
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<name sortKey="Bajpai, Manisha" sort="Bajpai, Manisha" uniqKey="Bajpai M" first="Manisha" last="Bajpai">Manisha Bajpai</name>
<name sortKey="Das, Kiron M" sort="Das, Kiron M" uniqKey="Das K" first="Kiron M." last="Das">Kiron M. Das</name>
<name sortKey="Dvorak, Katerina" sort="Dvorak, Katerina" uniqKey="Dvorak K" first="Katerina" last="Dvorak">Katerina Dvorak</name>
<name sortKey="Krasna, Mark J" sort="Krasna, Mark J" uniqKey="Krasna M" first="Mark J." last="Krasna">Mark J. Krasna</name>
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<region name="Pennsylvanie">
<name sortKey="Gibson, Michael K" sort="Gibson, Michael K" uniqKey="Gibson M" first="Michael K." last="Gibson">Michael K. Gibson</name>
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<name sortKey="Dhaliwal, Arashinder S" sort="Dhaliwal, Arashinder S" uniqKey="Dhaliwal A" first="Arashinder S." last="Dhaliwal">Arashinder S. Dhaliwal</name>
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<name sortKey="Clemons, Nicholas J" sort="Clemons, Nicholas J" uniqKey="Clemons N" first="Nicholas J." last="Clemons">Nicholas J. Clemons</name>
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<name sortKey="Clemons, Nicholas J" sort="Clemons, Nicholas J" uniqKey="Clemons N" first="Nicholas J." last="Clemons">Nicholas J. Clemons</name>
<name sortKey="Clemons, Nicholas J" sort="Clemons, Nicholas J" uniqKey="Clemons N" first="Nicholas J." last="Clemons">Nicholas J. Clemons</name>
<name sortKey="Phillips, Wayne A" sort="Phillips, Wayne A" uniqKey="Phillips W" first="Wayne A." last="Phillips">Wayne A. Phillips</name>
<name sortKey="Phillips, Wayne A" sort="Phillips, Wayne A" uniqKey="Phillips W" first="Wayne A." last="Phillips">Wayne A. Phillips</name>
<name sortKey="Phillips, Wayne A" sort="Phillips, Wayne A" uniqKey="Phillips W" first="Wayne A." last="Phillips">Wayne A. Phillips</name>
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<country name="Hong Kong">
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<name sortKey="Tong, Daniel" sort="Tong, Daniel" uniqKey="Tong D" first="Daniel" last="Tong">Daniel Tong</name>
</noRegion>
<name sortKey="Law, Simon" sort="Law, Simon" uniqKey="Law S" first="Simon" last="Law">Simon Law</name>
</country>
<country name="Argentine">
<noRegion>
<name sortKey="Pirchi, E Daniel" sort="Pirchi, E Daniel" uniqKey="Pirchi E" first="E. Daniel" last="Pirchi">E. Daniel Pirchi</name>
</noRegion>
</country>
<country name="Finlande">
<noRegion>
<name sortKey="R S Nen, Jari" sort="R S Nen, Jari" uniqKey="R S Nen J" first="Jari" last="R S Nen">Jari R S Nen</name>
</noRegion>
</country>
<country name="Pays-Bas">
<region name="Hollande-Septentrionale">
<name sortKey="Parikh, Kaushal" sort="Parikh, Kaushal" uniqKey="Parikh K" first="Kaushal" last="Parikh">Kaushal Parikh</name>
</region>
<name sortKey="Krishnadath, Kausilia K" sort="Krishnadath, Kausilia K" uniqKey="Krishnadath K" first="Kausilia K." last="Krishnadath">Kausilia K. Krishnadath</name>
</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name>
</noRegion>
<name sortKey="Colleypriest, Benjamin J" sort="Colleypriest, Benjamin J" uniqKey="Colleypriest B" first="Benjamin J." last="Colleypriest">Benjamin J. Colleypriest</name>
<name sortKey="Farrant, J Mark" sort="Farrant, J Mark" uniqKey="Farrant J" first="J. Mark" last="Farrant">J. Mark Farrant</name>
<name sortKey="Griffiths, Leonard" sort="Griffiths, Leonard" uniqKey="Griffiths L" first="Leonard" last="Griffiths">Leonard Griffiths</name>
<name sortKey="Tosh, David" sort="Tosh, David" uniqKey="Tosh D" first="David" last="Tosh">David Tosh</name>
</country>
</tree>
</affiliations>
</record>

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